ScienceTechyNews: Diving into the details: A lipid-binding pocket is a target for new cancer therapies

Cell growth is tightly controlled; however, cancer cells overcome the normal growth controls and proliferate uncontrollably. Researchers at the Medical University of South Carolina examined the molecular details underlying the interaction of ceramide, a lipid that plays a critical role in several signaling pathways, with a protein complex involved in modulating cell growth. They showed that ceramide and a similar compound, fingolimod, disrupt the interaction of SET with PP2A to repress cell growth.

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